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. 2023 Apr 29;6(2):242–256. doi: 10.20517/cdr.2022.113

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© The Author(s) 2023.

© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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The importance of WIP1 in the p53 signaling pathway and its Protein–protein interaction network. (A) The p53 pathway map (map04115) was provided using the KEGG database. The red stars above each gene represent the genes whose activity is affected by WIP1 via dephosphorylation; (B) WIP1 Protein-protein interaction network was visualized by STRING with high confidence (0.7). The edges represent protein-protein associations which are meant to be specific and meaningful. This does not necessarily mean they are physically binding to each other. MDM2: Mouse Double Minute 2 Homolog; WIP1: Wild-type p53-Induced Phosphatase 1.