Table 2.
Representative examples of nanocarrier - marketed products or products in clinical trials with their indications
| Classification | Compound | Indications |
| Liposome | Liposomal doxorubicin (Doxil, Janssen) | Karposi’s sarcoma, ovarian cancer, multiple myeloma |
| Liposomal vincristine (Marqibo, Spectrum pharmaceuticals) | Acute lymphoblastic leukemia | |
| Liposomal irinotecan (Onivyde, Ipsen biopharmaceuticals) | Pancreatic cancer | |
| Liposomal daunorubicin and cytarabine (Vyxeos, Jazz pharmaceuticals) | Acute myeloid leukemia with myelodysplasiarelated changes | |
| Liposomal lurtotecan (OSI-211, phase-II)[102] | Recurrent ovarian cancer, recurrent small-cell lung cancer | |
| Liposomal paclitaxel (LEP ETU, phase-I/II)[103] | Advanced solid tumors | |
| Liposomal oxaliplatin (Aroplatin, phase-II)[104] | Advanced colorectal cancer | |
| Liposomal interleukin-2 (Oncolipin, phase-II)[105] | Immune stimulant for use with a liposomal vaccine against non-small cell lung cancer | |
| Polymeric | Leuprolide acetate and polymer (Eligard, Tolmar) | Prostate cancer |
| Pegfilgrastim (Neulasta, Amgen) | Chemotherapy-induced neutropenia | |
| Dantrolene sodium (Ryanodex, Eagle pharmaceuticals) | Malignant hypothermia | |
| Pegaspargase (Oncaspar, Baxalta U.S.) | Acute myeloid leukemia | |
| PEG-PLA/paclitaxel (Genexol-PM) | Breast and lung cancer | |
| PLGA/goserelin acetate (Zoladex) | Prostate and breast cancer | |
| PLGA/leuprolide acetate (Lupron depot) | Prostate cancer and endometriosis | |
| PLGA/triptorelin pamoatea (Trelstar) | Advanced prostate cancer | |
| PLGA/leuprolide acetate (Eligard) | Advanced prostate cancer | |
| HPMA-copolymer-doxorubicin (PK1; FEC28069, phase-II)[106] | Lung cancer, breast cancer, and various other cancers | |
| PEG-camptothecin (Prothecan, phase-II)[107] | Various cancers | |
| Paclitaxel-poliglumex (CT-2103; Xyotax, phase-III)[108] | Non-small cell lung cancer, ovarian cancer | |
| Protein nanoparticles | Denileukin diftitox (Ontak, Eisai) | Cutaneous T-cell lymphoma |
| Albumin-bound paclitaxel (Abraxane, Celgene) | Breast cancer, non-small-cell lung cancer, pancreatic cancer | |
| Metal-based nanoparticles | Colloidal gold nanoparticles coupled to TNF and PEG-thiol (CYT-6091; Cyt-immune Sciences, phase 1)[109] | Solid tumors |
PEG: Poly ethylene glycol; PLA: poly lactic acid; PLGA: poly (lactide-co-glycolide); TNF: tumor necrosis factor.