Extended Data Fig. 9. Tumor histology and imaging through thick tissue.
(a) Fluorescence micrograph of a 100 μm-thick tissue section from an uninduced tumor. The red color shows TO-PRO-3 nuclear stain; GFP and BFP fluorescence were not observed for this control tumor. Scale bars represent 2 mm. (b) Quantification of xAM SBR of MDA-MB-231-mARGAna cells imaged under >1 cm of beef liver tissue (n = 7) or under PBS (n = 4) as a function of transducer voltage. Thick lines represent the mean of replicates and thin lines represent ± standard deviation. (c) Representative xAM/B-mode overlay of MDA-MB-231-mARGAna cells imaged under liver tissue using L10-5v transducer at 18 V for xAM.