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. 2023 Jun 10;26(7):107095. doi: 10.1016/j.isci.2023.107095

Figure 6.

Figure 6

Analysis of paired biopsies reveals epigenetic therapy-induced augmentation of both tumor accumulation and tumor infiltration of CD8+ T cells

(A) CD8α H-score comparison baseline vs. on-treatment (n = 8 paired samples). Statistical significance by Wilcoxon Signed Ranked Test, ∗ indicates p value < 0.05, mean and individual sample values are plotted.

(B) CD8+ T cell infiltration status baseline vs. on-treatment (n = 8 paired samples).

(C) CCL5 tumor and tumor microenvironment H-score comparison baseline vs. on-treatment (n = 8 paired samples). Statistical significance by Wilcoxon Signed Ranked Test, ∗ indicates p value < 0.05, mean and individual sample values are plotted.

(D) Representative CD8α and CCL5 single-plex IHC. Top panel: baseline, bottom panel: on-treatment combination epigenetic treatment (Azacitidine + Entinostat). Left panel and right panel are representatives of two independent patients. Representative scale bar provided in the left image of figure panel.