Fig. 1.

ncRNAs in cancers ncRNAs in cancer can affect cancer initiation, progression via three ways: act as oncogenes, cancer suppressors or affect cancer metastasis. When it is used as oncogene, lncRNA H19, miR-21 and miR-17-92 mainly promote the target, while lncRNA PVT1, miR-372/373 and lncRNA HOTAIR inhibit the target. As tumor suppressor, miR-34 and lncRNA MEG3 both promote target P53, and lncRNA MEG3, it can affect autophagy and inhibit cancer, and miR-15a and miR-16-1 affect BCL-2 and inhibit cancer. When lncRNA plays a role in influencing tumor metastasis, it affects the target, thus affecting the occurrence of cancer