Table 1.
MicroRNA in cancer
| MicroRNA | Location | Targets | Expression | Roles | References |
|---|---|---|---|---|---|
| Let-7 | Vulnerable intergenic regions associated with cancer. |
RAS, HMGA2 |
Downregulated in lung and breast cancer. |
TS | [7, 65] |
|
miR-15a miR-16-1 |
Chromosome13q14 Region |
BCL-2 | Upregulated in CLL | TS | [7] |
| miR-29 |
Chromosome 7q23, Chromosome1q32 |
MCL-1 | Downregulated in CLL, lung cancer. etc. | TS | [7] |
| miR-34a/b/c |
miR-34a is located in Chromosome 1p36.22, miR-34b/c is located in chromosome 11q23.1 |
P53 Wnt |
Downregulated in rectal, breast and prostate cancer, and inhibits tumor invasion and migration. | TS | [2, 62, 73] |
| miR-155 | Chromosome 21q23 | c-maf | Upregulated in lung and breast cancer, CLL, AML. | OG | [22] |
| miR-21 | Intimal region of the TMEM49 gene |
Ras MEK EPK |
Upregulated in pancreatic and liver cancer, glioblastoma. | TS | [70, 71] |
|
miR-17-92 cluster |
Chromosome 13q31.3 | C-myc | Upregulated in Solid tumors and hematological malignancies. | OG | [73] |
TS tumor suppresor, OG oncogenes