Table 3.
LncRNA | Cancer types | Mechanism | Roles | References |
---|---|---|---|---|
GAS5 | Breast cancer, glioblastoma, SCC | Affects GR signaling ,interacts with miRNA, reduces cell proliferation and increase apoptosis | TS | [22, 33] |
LUNAR1 | T-ALL | Activation of IGF1R expression in cis cells to regulate T cell growth | OG | [33] |
NEAT1 | Liver and ovarian cancer, melanoma | It is a target gene of P53 and can activate oncogenes | OG | [33] |
LUCAT1 | Kidney cancer | Promoting proliferation and invasion of clear cell renal cell carcinoma via AKT/GSK-3β signaling pathway | OG | [100] |
GAS6-AS2 | Bladder cancer | Induction of G1 arrest promotes tumor growth, and miR-298 sponge regulates CDK9 expression. | OG | [103] |
FOXD2-AS1 | Gastric cancer | Promote cell cycle progression and accelerate cell proliferation | OG | [104] |
lncRNA-p21 | Rectal cancer | Involved in the transcriptional regulation of P21 and P53 | TS | [33] |
NAMA | PTC | Regulated by the MAP pathway | TS | [113] |
PTCSC3 | PTC | Inhibit the expression of S100A4, VEGF and MMP9,inhibit the growth and invasion of TC cells | TS | [113] |
T-ALL T cell acute lymphoblastic leukemia, SCC squamous cell carcinoma, PTC papillary thyroid cancer, TC thyroid cancer