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. 2023 Jul 13;14:4084. doi: 10.1038/s41467-023-39404-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Study protocol of digoxin (DG) or alpelisib (ALP) administration in NASH model mice with CDAHFD. b Body weight of control and drugtreated mice. c ORO staining of liver sections. Scale bars, 1 mm. d Liver TG and NEFA content. e Serum TG and NEFA levels. f, g Real-time PCR assessing the expression of inflammation- (f) and fibrosis- (g) related genes in liver tissue. h Sirius red staining of liver sections. Scale bars, 200 µm. i ORO staining of liver sections of liver-specific Atg5 knockout mice fed CDAHFD. j Liver TG and NEFA content of liver-specific Atg5 knockout mice fed CDAHFD. k Real-time PCR assessing the expression of inflammation-related genes in Atg5 knockout liver tissue. Data are presented as mean ± SD of n = 8–9 (a–h) and n = 5–6 (i–k). P values calculated by one-way ANOVA with Dunnett’s multiple comparison test. Source data are provided as a Source data file.