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. 2023 Jul 13;13:259. doi: 10.1038/s41398-023-02561-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A shMbd2 viral construct reduces Mbd2 mRNA. Mbd2 mRNA levels were reduced in the hippocampus from shMbd2-infused mice compared with scramble control-infused mice. Scramble n = 6, shMbd2 n = 4 (T test). B Representative micrograph of Mbd2 immunolabeling in hippocampal slices from Scramble- and shMbd2- infused mice. Scale bar: 200 μm. C Locomotion in Open-field box. D Self-grooming during open field. E Number of self-grooming bouts. F Average self-grooming bout duration. G Discrimination ratio in object-location memory test. H Social interaction test. I Time in the light compartment of the Dark-Light Box and J number of entries to the light side. Data are presented as mean ±SEM *p < 0.05, for wild-type vs Mbd2−/− (t-test). # p < 0.05 for wild-type over chance (50%) exploration (one-sample t-test). Scramble n = 7, shMbd2 n = 6.