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Mechanism of mitochondrial folate metabolism in hepatic stellate cells to maintain TGF-β1 signaling. Mitochondrial folate metabolism/α-linolenic acid (ALA) exhaustion/TGF-βR1 reproduction is a feedforward signaling to sustain profibrotic TGF-β1 signaling. Targeting mitochondrial folate metabolism blocks TGF-β1 signaling sustainability and enforces HSC homeostasis restoration. HSC, hepatic stellate cell.
