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. 2023 Jul 13;9:59. doi: 10.1038/s41523-023-00564-9

Fig. 1. The effect of TTP488 and FPS-ZM1 on tumor growth and metastases in breast cancer mouse models.

Fig. 1

a 4175 cells were injected into the mammary fat pad of immunocompromised NSG mice, and mice were treated IP twice per week with 1 mg/kg TTP488 or FPS-ZM1 (or vehicle (DMSO) control). Tumor size was measured every 3 days, and (b) at the end of the experiment, tumors were weighed. Data shown are from 4–8 mice per group (repeated twice). c Immunohistochemical analysis of 4175/NSG tumors for proliferation (Ki67). d Immunohistochemical analysis of human CK7 to assess for metastasis in 4175/NSG mouse lung tissue. e 4T-1 cells were tail-vein injected into BALBc mice, and mice were treated IP twice per week with 1 mg/kg TTP488 or FPS-ZM1 (or vehicle (DMSO) control). Representative IVIS images at day 13 are shown from n = 11 per group. f Total flux measured from IVIS images is shown. G Surface lung metastases count performed at necropsy. Values shown are mean ± SD. Statistical analysis: one or two-way ANOVA with Dunnett’s multiple comparisons test. *p < 0.05; **p < 0.01; ***p < 0.001, ****p < 0.0001.