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. 2023 Jul 13;14(7):418. doi: 10.1038/s41419-023-05954-2

Fig. 2. Interleukin (IL)-10 signaling blockade leads to exacerbated lung inflammation after lipopolysaccharide (LPS) exposure.

Fig. 2

A Flow cytometry analysis of macrophage cell numbers in mice lung (n = 6–8). B Geo MFI of CD86 on macrophages. (n = 6–8). C Flow cytometry analysis of M1 macrophage numbers in mice lung (left); RT-PCR to test the expression level of iNOS mRNA (right) (n = 6–10). D The mRNAs of IL-6 and TNF-α were detected in lung homogenates (n = 4–10). E Cytokine levels in bronchoalveolar lavage fluid samples of different groups (n = 5–9). F Neutrophils (CD11b+, Ly6G+) in the lungs as a proportion of live events. The total number of cells was then multiplied by the ratio to give the total neutrophil count. (n = 5–9). G Chemokines associated with neutrophils (n = 5–11). A–G Experiments were conducted 4 days after LPS exposure. A–G Student’s t-test was used for the statistical analyses.