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. 2023 Jul 13;14(7):418. doi: 10.1038/s41419-023-05954-2

Fig. 6. Exogenous IL-10 promotes acute lung injury (ALI) recovery.

Fig. 6

A Mice body weight was measured daily after intranasal (i.n.) lipopolysaccharide (LPS) administration (n = 8). LPS + IL-10 group was instilled with 0.1 μg of IL-10 recombinant protein on days 1 and 3 after LPS exposure. B Clinical signs in mice were observed (n = 8). C On day 4, after 50 μg i.n. LPS administration, bronchoalveolar lavage fluid of the WT and WT + IL-10 mice were harvested. Total cells and different types of BALF cell were counted (n = 8). D mRNA levels of IL-6, TNF-α, IL1-β, and IL-17, were detected in lung homogenates. E mRNA levels of KC, GPR-35, MIP-2, and GM-CSF were detected in lung homogenates. F The representative image of HE-stained lung sections (n = 4). Scale bars, 100 μm. G The inflammation score of the HE-stained sections (n = 4). A, B Two-way ANOVA was used for the statistical analyses. C–E, G One-way ANOVA was used for the multiple group’s statistical analyses (blue stars). Student’s t-test was used for the two groups’ statistical analyses (black stars).