Table 2.

Multivariable Cox proportional hazard model evaluating the association between log-transformed serum neurofilament light chain (sNfL) levels and all-cause mortality through December 2019 in specific subgroups of the studied population

Population	All-cause mortality
	HR	95% CI	p-Value
Age
< 60 years	2.57	1.65–4.01	< 0.001
≥ 60 years	2.67	1.66–4.32	0.001
Sex
Males	3.05	1.71–5.44	0.001
Females	1.89	1.06–3.39	0.034
Renal function
eGFR < 90 mL/min	3.02	1.66–5.50	0.001
eGFR ≥ 90 mL/min	2.38	1.35–4.18	0.005
Adiposity
BMI < 30 kg/m2	3.52	1.91–6.50	0.001
BMI ≥ 30 kg/m2	1.93	1.30–2.88	0.003
Race-ethnicity
Non-Hispanic white	2.51	1.60–3.96	0.001
Other ethnicities	2.01	1.44–2.82	< 0.001
Cigarette smoke
Current smokers	2.63	1.18–5.87	0.022
Never/former smokers	2.61	1.78–3.84	< 0.001

Hazard ratios (HR) for all-cause mortality and related confidence intervals (CI) for a unit increase of log-transformed sNfL were adjusted for age, sex, race-ethnicity, chronic kidney disease, alcohol consumption, diabetes, cardiovascular disease, educational status and cigarette smoke