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. 2023 Jun 17;18(4):505–515. doi: 10.1007/s11523-023-00975-5

Table 4.

Tolerability overview of the Taiwanese subgroup (n = 56) and the overall RELAY safety population (n = 446)

Events, n (%) Taiwanese subgroup Overall RELAY safety populationa
RAM+ERL (n = 26) PBO+ERL (n = 30) RAM+ERL (n = 221) PBO+ERL (n = 225)
Any TEAE 26 (100) 30 (100) 221 (100) 225 (100)
Any grade ≥ 3 TEAE 16 (62) 9 (30) 159 (72) 121 (54)
Any TE-SAE 11 (42) 5 (17) 65 (29) 47 (21)
Discontinued due to AE 1 (4) 0 28 (13) 24 (11)
Discontinued due to SAE 0 0 10 (5) 9 (4)
AEs leading to death, on study treatment 0 0 2 (1) 0
AEs leading to death, within 30 days of discontinuation 0 0 4 (2) 0

aData published in Nakagawa et al. 2019 [20]

AE adverse event, ERL erlotinib, PBO placebo, RAM ramucirumab, SAE serious adverse event, TEAE treatment-emergent adverse event, TE-SAE treatment-emergent serious adverse event