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. 2023 Jul 13;14:4186. doi: 10.1038/s41467-023-39837-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Simulated true (A) vs observed (B) reduction in intact HIV DNA after therapies with 6 different efficacies each ranging from 2-fold to 100-fold reduction in intact proviruses (no reduction of defective proviruses) applied to reservoirs with 3 different initial intact fractions, for a total of 18 simulations. C True therapeutic efficacy vs observed therapeutic efficacy for the range of therapies, colored by misclassification fraction ranging from 0.5 to 8%. There are 3 dots of each color, for each x-value, representing the variability from the initial fraction. D True therapeutic efficacy vs observed therapeutic efficacy for the range of therapies, colored by initial fraction of intact to total HIV DNA ranging from 1/100 to 1/2. There are 3 dots of each color, for each x-value, representing the variability from the misclassification fraction.