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. 2023 Jul 13;14:4174. doi: 10.1038/s41467-023-39189-8

Fig. 2. FcR binding antibodies towards full-length Spike and RBD have rapid wane kinetics.

Fig. 2

A–D FcR antibody binding towards WT SARS-CoV-2 Spike was quantified in the baseline (prior to immunization, white, lane 1), 1- and 2-dose BNT162b2 mRNA (blue, lanes 2 and 3, waning periods in lanes 4 and 5), 1- and 2-dose CoronaVac (gray, lanes 6 and 7, waning periods in lanes 8 and 9) via Luminex systems serology. Y-axis represents the MFI of binding full-length WT SARS-CoV-2 Spike. Shown are box and whiskers, along with individual data points, which represent the mean of individual participants from each vaccine group (BNT162b2, n = 15 and CoronaVac, n = 34). The whisker above the box plot extends from the top quartile to the highest actual value that is within the 75th percentile + 1.5 * interquartile range. The whisker below the box plot extends from the lower quartile to the lowest actual value that is within 25th percentile + 1.5 * interquartile range. (A) FcγRIIA, (B) FcγRIIB, (C) FcγRIIIA, and (D) FcγRIIIB. E–H Same as (A–D), but for SARS-CoV-2 RBD. Note that Y-axis scales are not the same. All samples were assayed in technical duplicates. Kruskal-Wallis test was used for all panels (*p < 0.05 and **p < 0.01). All Kruskal–Wallis tests were two-sided, and no adjustments were made for multiple comparisons. The samples were assayed in technical duplicates. See also Supplementary Fig. 4 for SARS-CoV-2 Nucleocapsid and control results. Source data are provided as a Source Data file.