Skip to main content
. 2023 Jul 13;14:4174. doi: 10.1038/s41467-023-39189-8

Fig. 3. COVID-19 mRNA boosters can enhance responses of multiple Spike-specific antibody-subclasses and -isotypes, and functional Fcγ-receptor complexes.

Fig. 3

A Spike-specific IgG1 levels were measured at peak immunogenicity following the two-dose CoronaVac vaccination series (lane 1), during waning periods (lanes 2 and 3), and after mRNA boost (lane 4) for SARS-CoV-2 VOC (color legend shown on right). The Y-axis represents the MFI of the Spike from the VOC. Shown are means (solid line) with SEM for each VOC in the corresponding color in the shaded region. B Same as (A), but for the receptor-binding domains (RBD) of SARS-CoV-2 VOC. C Heatmap representation of binding for full-length Spike by antibody-subclasses and -isotypes and Fcγ-receptor complexes. Shown on the left are the description of CoronaVac doses, the subsequent waning period, and mRNA-vaccine booster, and on the right are the SARS-CoV-2 VOC or WT. The scale bar is shown to the right of the heatmap and represents MFI over baseline values. The values in each region represent the mean of values from individual participants from each vaccine group (BNT162b2, n = 15 and CoronaVac, n = 34). D Same as (C), but for the RBD of WT SARS-CoV-2 and VOC. The samples were assayed in technical duplicates. See also Supplementary Fig. 5. Source data are provided as a Source Data file.