FIGURE 1.

Characteristics of immune cell composition and plasma steroids. (A) Percentages of monocytes, lymphocytes and neutrophils in the peripheral blood mononuclear cell (PBMC) fraction of healthy controls and Cushing's syndrome (CS) patients. Cell counts were measured using a Sysmex XN‐450 automated hematology analyser (Sysmex, Kobe, Japan). (B) Plasma concentrations of cortisol and 11‐deoxycortisol from healthy controls and CS patients. Individuals receiving oral contraceptives were excluded from analysis. (C) Heatmap of correlation coefficients between plasma cortisol and 11‐deoxycortisol and PBMC fraction percentages. Data are presented as mean ± standard error of mean (SEM). ^** p < .01, ^*** p < .001, ^**** p < .0001, Mann–Whitney U‐test. The correlation between cell composition and steroids was assessed using Spearman's correlation.