Table 1.
# | CAR | scFv | mAb clone | Affinity (Kd) | CCR4 epitope | Reference |
---|---|---|---|---|---|---|
1 | KW_H2L | H to L | KW-0761 | ND (slow dissociation) | NT 12 to 29 (DESIYSNYYLYESIPKPC) | 11 |
2 | KW_L2H | L to H | ||||
3 | 1-49_H2L | H to L | mAb 1-49 | 77.98 nM | ND (combinatorial of NT and ECL) | 29 |
4 | 1-49_L2H | L to H | ||||
5 | 2-3_H2L | H to L | mAb 2-3 | 1.39 nM | ||
6 | 2-3_L2H | L to H | ||||
7 | h1567_H2L | H to L | h1567 | 2.54 nM | ||
8 | h1567_L2H | L to H |
Kd values are from data as antibodies but not as scFvs.
ECL, extracellular loop; ND, not determined; NT, N-terminus.