Figure 1.

Study approach for screening, enrolment and management of sick infants. *Signs of possible serious bacterial infection (PSBI): convulsions, not able to feed at all, stopped feeding well, severe chest indrawing, body temperature ≥38°C, body temperature <35.5°C, movement only when stimulated, no movement at all, fast breathing in <7 days. †[31]. ‡Clinically well on day 3 defined as absence of all signs of critical illness or CSI, laboratory test negative, and family lives in a catchment area where a follow-up can be accomplished. CSI – clinical severe infection, IV – intravenous, IM – intramuscular, PSBI – possible serious bacterial infection