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Table 9. ATTR stabilizers for the treatment of transthyretin amyloid cardiomyopathy.

Tafamidis Diflunisal AG10
Evidence FDA, EMA, and TFDA approved Off-label use Under investigation
Dose 61 mg (tafamidis meglumine) QD 250 mg BID N/A
Side effect No Fluid retention N/A
Renal dysfunction
GI bleeding

ATTR, transthyretin; BID, twice per day; EMA, European Medicines Agency; FDA, Food and Drug Administration; GI, gastrointestinal; N/A, not applicable; QD, once per day; TFDA, Taiwan Food and Drug Administration.