Table 9. ATTR stabilizers for the treatment of transthyretin amyloid cardiomyopathy.
Tafamidis | Diflunisal | AG10 | |
Evidence | FDA, EMA, and TFDA approved | Off-label use | Under investigation |
Dose | 61 mg (tafamidis meglumine) QD | 250 mg BID | N/A |
Side effect | No | Fluid retention | N/A |
Renal dysfunction | |||
GI bleeding |
ATTR, transthyretin; BID, twice per day; EMA, European Medicines Agency; FDA, Food and Drug Administration; GI, gastrointestinal; N/A, not applicable; QD, once per day; TFDA, Taiwan Food and Drug Administration.