Table 2.
Japanese Knee Osteoarthritis Measure (JKOM) and Japanese Orthopaedic Association (JOA) scores from weeks 0 to 12.
| 0 Week | 4 Week | 8 Week | 12 Week | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MSM Group | Placebo Group | Difference | p Value 1 | MSM Group | Placebo Group | Difference | p Value 1 | MSM Group | Placebo Group | Difference | p Value 1 | MSM Group | Placebo Group | Difference | p Value 1 | ||
| Mean ± SD | Mean ± SD | (95% CI) | Mean ± SD | Mean ± SD | (95% CI) | Mean ± SD | Mean ± SD | (95% CI) | Mean ± SD | Mean ± SD | (95% CI) | ||||||
| JKOM | Ⅰ:VAS | 37.9 ± 21.9 | 41.3 ± 20.7 | −3.4 (−12.9 to 6.1) |
0.478 | 34.1 ± 22.2 | 32.9 ± 21.0 | 1.2 (−8.4 to 10.8) |
0.801 | 25.3 ± 18.6 | 29.0 ± 22.3 | −3.7 (−12.9 to 5.4) |
0.416 | 24.4 ± 21.7 | 25.2 ± 22.1 | −0.7 (−10.5 to 9.0) |
0.881 |
| Ⅱ: Pain and stiffiness in knees | 6.8 ± 2.5 | 7.1 ± 3.3 | −0.4 (−1.7 to 0.9) |
0.566 | 5.2 ± 2.8 | 5.7 ± 3.9 | −0.5 (−2.0 to 1.0) |
0.548 | 4.1 ± 2.7 | 4.8 ± 3.4 | −0.7 (−2.1 to 0.7) |
0.306 | 2.7 ± 2.2 | 3.9 ± 3.4 | −1.2 (−2.4 to 0.1) |
0.073 | |
| Ⅲ: Condition in daily life | 4.4 ± 3.4 | 4.7 ± 3.4 | −0.3 (−1.8 to 1.2) |
0.674 | 2.9 ± 4.4 | 3.4 ± 4.6 | −0.5 (−2.5 to 1.5) |
0.645 | 2.5 ± 2.3 | 2.8 ± 4.1 | −0.3 (−1.8 to 1.1) |
0.643 | 1.5 ± 1.8 | 2.1 ± 3.1 | −0.6 (−1.7 to 0.5) |
0.300 | |
| Ⅳ: General activities | 4.6 ± 2.1 | 5.4 ± 2.4 | -0.8 (−1.8 to 0.2) |
0.118 | 3.7 ± 1.6 | 4.0 ± 1.6 | −0.3 (−1.0 to 0.5) |
0.478 | 3.2 ± 1.5 | 3.6 ± 1.7 | −0.4 (−1.1 to 0.3) |
0.263 | 2.7 ± 1.5 | 3.1 ± 1.5 | −0.5 (−1.1 to 0.2) |
0.153 | |
| Ⅴ: Health conditions | 2.5 ± 0.9 | 2.6 ± 0.9 | −0.1 (−0.5 to 0.2) |
0.461 | 1.8 ± 1.0 | 2.0 ± 1.2 | -0.2 (−0.7 to 0.3) |
0.415 | 1.6 ± 1.0 | 1.7 ± 1.1 | −0.2 (−0.6 to 0.3) |
0.476 | 1.2 ± 1.0 | 1.8 ± 1.2 | −0.6 (−1.0 to−0.1) |
0.027 * | |
| Total JKOM score | 18.2 ± 6.7 | 19.9 ± 7.5 | −1.6 (−4.8 to 1.5) |
0.305 | 13.6 ± 7.7 | 15.0 ± 10.1 | −1.4 (−5.4 to 2.6) |
0.492 | 11.3 ± 5.4 | 13.0 ± 8.4 | −1.6 (−4.8 to 1.5) |
0.307 | 8.1 ± 4.2 | 10.9 ± 7.6 | −2.8 (−5.5 to−0.1) |
0.046 * | |
| JOA | Total score | 95.9 ± 5.9 | 95.9 ± 5.0 | 0.0 (−2.4 to 2.5) |
0.972 | 95.4 ± 5.2 | 96.5 ± 5.1 | −1.1 (−3.4 to 1.2) |
0.352 | 96.5 ± 4.1 | 96.5 ± 4.4 | −0.1 (−1.9 to 1.8) |
0.958 | 96.4 ± 5.3 | 96.6 ± 5.3 | −0.2 (−2.6 to 2.1) |
0.843 |
CI, confidence interval; 1 Welch’s t-test assessed differences between the MSM and placebo groups for 0, 4, 8, and 12 weeks. * p < 0.05 between the MSM and placebo groups.