Table 2.
Kiwifruit allergens and their main characteristics.
| Allergen | Biochemical Name | Molecular Weight | Clinical Significance |
|---|---|---|---|
| Act d 1 | Cysteine protease (actinidin) | 30 kDa | Major allergen related to systemic reactions |
| Act d 2 | Thaumatin-like protein | 24 kDa | Major allergen |
| Act d 3 | 40 kDa | Minor allergen | |
| Act d 4 | Phytocystatin | 11 kDa | Minor allergen |
| Act d 5 | Kiwellin | 28 kDa | Minor allergen |
| Act d 6 | Pectin methylesterase inhibitor | 18 kDa | Minor allergen |
| Act d 7 | Pectin methylesterase | 50 kDa | Minor allergen |
| Act d 8 | Pathogenesis-related protein, PR-10, Bet v 1 family member | 17 kDa | Major allergen, negative predictive risk factor for systemic reactions |
| Act d 9 | Profilin | 14 kDa | Minor allergen |
| Act d 10 | nsLTP1 | 10 kDa | Minor allergen associated with mild symptoms, mainly in southern Europe |
| Act d 11 | Major latex protein/ripening-related protein (MLP/RRP), Bet v 1 family member | 17 kDa | Major allergen |
| Act d 12 | Cupin, 11S globulin, kiwifruit seed storage protein | 50,207.304 Da (mass spectrometry), six peptide sequences (C0HJF9, to be released upon publication) | Major allergen |
| Act d 13 | 2S albumin, kiwifruit seed storage protein | 11,359.6 Da (mass spectrometry), four peptide sequences (C0HJG, to be released upon publication) | Minor allergen |