Table 1.
Comparative genetic effect of putative causal variants across East Asian and European populations.
| RS_ID | Gene | POP | Phenotype | EUR_AF | EAS_AF | PIP | Effect_cond_EUR | SE_cond_EUR | Effect_cond_EAS | SE_cond_EAS | P_het | Sig_het |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs7556897 | CCL20 | EAS | CD | 0.3429 | 0.2024 | 0.409 | 0.0347 | 0.0172 | 1.93E-01 | 0.0315 | 1.08E-05 | adj.P < 0.05 |
| rs6856616 | LINC02513 | EAS | CD | 0.0596 | 0.2321 | 0.874 | 0.1109 | 0.0315 | 2.84E-01 | 0.0254 | 1.83E-05 | adj.P < 0.05 |
| rs7043505 | TNFSF15 | EAS | CD | 0.4503 | 0.6895 | 0.488 | 0.0310144 | 0.0271579 | 4.28E-01 | 0.0392266 | 9.28E-17 | adj.P < 0.05 |
| rs3812565 | CARD9 | EUR | CD | 0.3549 | 0.1885 | 0.81471455 | 0.178248 | 0.0163733 | 4.00E-03 | 0.0284994 | 1.15E-07 | adj.P < 0.05 |
| rs7915475 | AC067752.1 | EUR | CD | 0.3012 | 0.1468 | 0.52844728 | -0.105578 | 0.0182737 | 0.0274657 | 0.0374278 | 0.00140178 | adj.P < 0.05 |
| rs11195128 | DUSP5 | EAS | CD | 0.3201 | 0.1478 | 0.949 | 0.113 | 0.0172 | 2.82E-01 | 0.0348 | 1.39E-05 | adj.P < 0.05 |
| rs7307562 | LRRK2 | EUR | CD | 0.393 | 0.494 | 0.9999 | -0.0813516 | 0.0165517 | 0.00591389 | 0.0227686 | 0.0019344 | adj.P < 0.05 |
| rs9889296 | CCL2 | EUR | CD | 0.3231 | 0.5496 | 0.51160938 | -0.1523 | 0.0182 | -3.33E-02 | 0.023 | 4.96E-05 | adj.P < 0.05 |
| rs2427537 | ZBTB46 | EAS | CD | 0.4702 | 0.0437 | 0.967 | 0.0127391 | 0.0169923 | -2.21E-01 | 0.0552614 | 5.38E-05 | adj.P < 0.05 |
| rs12628495 | CSF2RB | EAS | CD | 0.0895 | 0.3393 | 0.519 | -0.0476638 | 0.0263475 | 2.51E-01 | 0.026149 | 9.03E-16 | adj.P < 0.05 |
| rs4655215 | RNF186 | EUR | UC | 0.291 | 0.47 | 1 | -0.133951 | 0.0186741 | -0.0273661 | 0.0291071 | 0.00205579 | adj.P < 0.05 |
The sample sizes used to derive ORs in East Asian and European populations were 22 828 and 40 266 for CD, and 22 318 and 45 975 for UC, respectively. Only non-Finnish European samples were used in the European analysis. Cochran's Q test (two-sided) was used for testing heterogeneity. We chose the number of putative causal variants tested for the correction such as an adjusted (adj.) P < 0.05 for CD or UC. EAS, East Asian population; EUR, European population.