Figure 5.

Effect of ARE treatment on body weight and cardiac function in BALB/c breast cancer mice with DOX chemotherapy. Quantified comparison of the body weight (A), blood pressure (B), and heart rates (C) among BALB/c breast cancer mice with Sham, ARE (150 mg/kg), DOX (2.4 mg/kg), and ARE (150 mg/kg) + DOX (2.4 mg/kg) treatments. ARE treatment alleviated body weight loss and abnormal cardiac function induced by DOX chemotherapy in BALB/c breast cancer mice. a: sham, b: ARE, c: DOX, d: ARE+DOX. (N =  8 for each group; values are presented as the mean  ±  SEM, one-way ANOVA followed by the Student–Newman–Keuls multiple comparisons post hoc test).