Effect of ARE treatment on immunodeficiency in BALB/c breast cancer mice with DOX chemotherapy. Quantified comparison of blood IgG (A), IgA (B), and IgE (C) levels among BALB/c breast cancer mice with Sham, ARE (150 mg/kg), DOX (2.4 mg/kg), and ARE (150 mg/kg) + DOX (2.4 mg/kg) treatments. ARE treatment enhanced the serum IgG and IgA levels but reduced the IgE level in the DOX chemotherapy of the 4T1 breast cancer cells. a: sham, b: ARE, c: DOX, d: ARE+DOX. (N = 3 for each group; values are presented as the mean ± SEM, one-way ANOVA followed by the Student—Newman–Keuls multiple comparisons post hoc test).