Figure 4.

(a) Average stiffness and (b) force at equilibrium in response to an indentation compressive strain (amplitude of 0.7 mm—10% of sample’s height—speed of 0.07 mm/s) for biomaterials with different concentrations of thrombin (0.0, 0.25, 0.5, and 0.1 NIH/mL) as well as for PRP. The presence of additional thrombin appears to leave the mechanical properties of the completely coagulated clot unchanged. Both the stiffness and the force at equilibrium remained stable across every thrombin concentration tested. A difference is, however, noticeable between the stiffness of the biomaterial and the stiffness of PRP, indicating that the presence of CS increases the resistance of the biomaterial to compression. CS does not appear to have an impact on the equilibrium force. N = 2, and n = 3.