Table 2. Results of univariate analysis of DCE-MRI and ADC quantitative parameters for predicting pCR before NACT and after 2 cycles of NACT.
| Parameters | npCR (n=49) | pCR (n=25) | t/U | P value |
|---|---|---|---|---|
| Ktrans** (min−1) | 0.24 (0.20, 0.29) | 0.29 (0.24, 0.32) | 426 | 0.033 |
| Kep** (min−1) | 0.83 (0.64, 1.04) | 0.96 (0.85, 1.20) | 442 | 0.052 |
| Ve** | 0.28 (0.22, 0.37) | 0.25 (0.20, 0.34) | 732 | 0.172 |
| ADC* (×10−3 mm2/s) | 0.78±0.14 | 0.80±0.11 | −0.49 | 0.622 |
| ΔDmax%** (%) | −24.31 (−8.9, −33.1) | −26.79 (−11.1, −37.4) | 467 | 0.101 |
| ΔKtrans%* (%) | −13±0.46 | −62±0.16 | 6.68 | <0.001 |
| ΔKep%** (%) | −8.12 (−35.21, 20.54) | −42.34 (−68.76, −28.83) | 907 | 0.001 |
| ΔVe%** (%) | 7.23 (−20.01, 30.23) | −16.45 (−46.91, 34.67) | 723 | 0.210 |
| ΔADC%** (%) | 9.23 (−4.41, 25.52) | 44.56 (31.72, 61.73) | 234 | <0.001 |
Data are presented as mean ± standard deviation or median (upper and lower quartiles). *, independent two-sample t-test; **, Mann-Whitney U test. DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; ADC, apparent diffusion coefficient; Ktrans, transfer constant; Kep, rate constant; Ve, relative extravascular extracellular space; pCR, pathologic complete response; NACT, neoadjuvant chemotherapy.