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. 2023 Jun 1;10(8):nwad165. doi: 10.1093/nsr/nwad165

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© The Author(s) 2023. Published by Oxford University Press on behalf of China Science Publishing & Media Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — In vivo performance of the paracrine products of 3D micropatterned MSCs on skin wound regeneration. (a) Traces of wound-bed closure during 14 days (day 0, 3, 7 and 14) for different groups based on rat full-thickness cutaneous wounds. (b) Wound healing rates for each group on day 3, 7 and 14. (c and d) Quantification and representative immunofluorescent images of neovascularization for each group on day 7. (e) Skin regeneration in the wound site was assessed by H&E staining for each group on day 14. (f) Immunofluorescent images of CK-10 indicated the epithelial reconstruction for each group. The data are represented as the mean ± SD, * p < 0.05, ** p < 0.01.