Table 5.

Studies on clinical efficacy of CBD-based products in the treatment of skin diseases in dogs.

Study design	Treatment	Results	References
Retrospective study to examine the effect of a 10% CBD-containing broad-spectrum hemp oil as a supplemental treatment for canine atopic dermatitis in 8 dogs.	Initial dose: 0.07 to 0.25 mg/kg of CBD orally twice daily. The dose was increased depending on the skin condition of each dog and the observed response at 0.125 mg/kg. Administration for at list 8 weeks.	CBD decreased the occurrence of pruritus in dogs with canine atopic dermatitis.	(83)
Randomized, double-blinded and placebo-controlled trial to determine if CBD/CBDA-rich hemp extract (in gelatin capsules) decreased pruritus and cutaneous lesions in 17 dogs with atopic dermatitis.	2 mg/kg of CBD/CBDA twice daily orally for 28 days.	CBD/CBDA does not affect lesion severity yet does have a positive effect on pruritus as an adjunct therapy in some dogs with atopic dermatitis.	(82)
Randomized complete block design, placebo controlled, to determine the influence of CBD treats on the daily activity in adult dogs.	2.5 mg/kg (LOW) and or 5.0 mg/kg (HIGH) of CBD per day (split in 2 administrations) orally for 7 days before and another 14-day during collection of activity.	CBD (LOW and HIGH) did not alter the total daily activity points or activity duration but tended (p = 0.071) to reduce total daily scratching compared with the control.	(84)