. 2023 Jun 30;10:1153926. doi: 10.3389/fcvm.2023.1153926

Table 2.

Weighted associations of calendar period and prevalence of elevated cardiovascular risk by sex^a.

Calendar Period	Sample size^b	Adjusted for Age	Multivariable Adjusted^c	Multivariable Adjusted, except Age
Both sexes^d
2001–2004	3,931	1.00 (reference)	1.00 (reference)	1.00 (reference)
2005–2008	4,440	0.82 (0.69–0.98)	0.80 (0.67–0.96)	1.02 (0.89–1.17)
2009–2012	4,789	0.69 (0.57–0.83)	0.65 (0.53–0.80)	1.08 (0.94–1.23)
2013–2016	4,900	0.80 (0.66–0.96)	0.78 (0.65–0.92)	1.33 (1.17–1.51)
2017–2020	3,417	0.64 (0.53–0.78)	0.63 (0.51–0.78)	1.36 (1.16–1.61)
P for linear trend^e		<0.001	<0.001	<0.001
Male
2001–2004	1,984	1.00 (reference)	1.00 (reference)	1.00 (reference)
2005–2008	2,162	0.75 (0.60–0.95)	0.74 (0.58–0.94)	1.01 (0.85–1.20)
2,009–2012	2,333	0.75 (0.59–0.97)	0.70 (0.54–0.90)	1.22 (1.03–1.45)
2013–2016	2,290	0.76 (0.61–0.96)	0.72 (0.57–0.90)	1.38 (1.18–1.60)
2017–2020	1,655	0.61 (0.48–0.78)	0.57 (0.44–0.73)	1.40 (1.14–1.71)
P for linear trend^e		<0.001	<0.001	<0.001
Female
2001–2004	1,947	1.00 (reference)	1.00 (reference)	1.00 (reference)
2005–2008	2,278	0.93 (0.73–1.19)	0.94 (0.74–1.20)	1.03 (0.86–1.24)
2009–2012	2,456	0.61 (0.50–0.75)	0.61 (0.49–0.76)	0.91 (0.78–1.06)
2013–2016	2,610	0.85 (0.65–1.12)	0.88 (0.68–1.15)	1.27 (1.07–1.51)
2017–2020	1,762	0.68 (0.52–0.90)	0.73 (0.54–0.99)	1.32 (1.07–1.64)
P for linear trend^e		0.01	0.06	0.001

^{^a}

Elevated cardiovascular risk was defined as a projected 10-year risk of atherosclerotic cardiovascular disease of 7.5% or greater using the Pooled Cohort Equations.

^{^b}

Total sample size for male and female are 10,424 and 11,053 after excluded participants with missing values for education level, poverty index, and insurance status.

^{^c}

Adjusted for age, race/ethnicity, education level, poverty index, and insurance status, including any significant 2-way interactions.

^{^d}

All of the models for both sexes combined include sex as a covariate.

^{^e}

The statistical significance of a linear trend from 2001 to 2004 through 2017–2020 was assessed using the weighted regression and modeling the midpoint of each time period.