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. Author manuscript; available in PMC: 2023 Jul 14.
Published in final edited form as: Kidney Int. 2022 Nov 25;103(3):565–579. doi: 10.1016/j.kint.2022.10.023

Figure 7: TNF effects on kidney and immune cell types by single nucleus RNAseq from glomerular-depleted biopsies.

Figure 7:

(A) UMAP plot of snRNAseq profiles from TI of selected NEPTUNE participants found to have elevated TNF activation scores (TNF high) and low to moderate TNF activation scores (TNF low) and (B) Single nuclear cluster expression of CCL2 and TIMP1 by TNF activation status. Cell type specific markers were based on Lake et al, 202128.

Abbreviations: ATL = ascending thin limb cells; DCT = distal convoluted tubule cells; DTL = descending thin limb cells; EC-GC = glomerular endothelial cells; FIB = fibroblast cells; Immune = several types of immune cells; PC/IC = principal cells / intercalated cells; POD = podocytes; PT = proximal tubule cells; TAL = thick ascending limb cells.