Table 1.
Clinical characteristics of participants summarized by cluster identity and cohort
| NEPTUNE | ALL (N = 220) |
Cluster1 (N = 85) |
Cluster 2 (N = 76) |
Cluster 3 (N = 59) |
P-value |
|---|---|---|---|---|---|
| AGE mean (sd) | 28.2 (21.7) | 22.3 (19.5) | 26.8 (22.6) | 38.5 (20.0) | < 0.0001 |
| Female (%) | 89 (40) | 33 (39) | 30 (39) | 26 (44) | 0.82 |
| Adult (%) | 112(59) | 31(36) | 35(46) | 46(78) | < 0.0001 |
| eGFR mean (sd) | 89.5 (46.8) | 102.1 (40.7) | 104.2 (48.9) | 52.3 (29.2) | < 0.0001 |
| Albumin mean (sd) | 3.62 (0.89) | 3.68(0.86) | 3.62(0.89) | 3.54(0.95) | 0.3916 |
| FSGS (%) | 114 (52) | 32 (38) | 37 (49) | 45 (76) | < 0.0001 |
| UPCR median (IQR) | 2.76 (1.0, 7.04) | 1.9 (0.6, 7.1) | 2.56 (1.02, 5.5) | 5.35 (2.0, 10.6) | <0.0001 |
| % IF median (IQR) | 4 (0, 16) | 1.5 (0,5) | 3 (0, 8) | 20 (10, 55) | <0.0001 |
| Disease duration prior to biopsy (months) mean (sd) | 29.47 (69.46) | 26.78 (46.56) | 18 (50.6) | 49 (108) | 0.30 |
| On RAAS Blockade (%) | 86 (39) | 34 (40) | 26 (34) | 26 (44) | 0.0005 |
| On IST (%) | 101 (46) | 49 (58) | 37 (49) | 15 (25) | 0.0005 |
| ERCB | Cluster 1 (N = 18) |
Cluster 2 (N = 4) |
Cluster 3 (N = 8) |
P-value | |
|
| |||||
| Age mean (sd) | 42.2 (19.0) | 29.4 (6.6) | 49.2 (18.3) | 0.63 | |
| Female (%) | 10 (56) | 1 (25) | 3 (38) | 0.59 | |
| eGFR mean (sd) | 92.2 (34.5) | 119.0 (4.0) | 43.2 (31.0) | 0.02 | |
| FSGS (%) | 8 (44) | 2 (50) | 7 (87) | 0.135 | |
| H3 Africa | Cluster1 (N = 14) |
Cluster 2 (N = 16) |
Cluster3 (N = 5) |
P-value | |
|
| |||||
| Age mean (sd) | 24.1 (10.2) | 30.0 (14.1) | 30.8 (10.7) | 0.19 | |
| Female (%) | 3 (21) | 4 (25) | 0 (0) | 0.90 | |
| eGFR mean (sd) | 89.8 (42.6) | 109.8 (14.7) | 25.8 (11.7) | 0.03 | |
| FSGS (%) | 7 (50) | 4 (25) | 4 (80) | 0.07 | |
| UPCR median (IQR) | 1.4 (1.1, 2.2) | 1.1 (0.3, 2.8) | 3.6 (1.8, 7.5) | 0.05 | |
| % IF median (IQR) | 0 (0, 9) | 0 (0, 1) | 40 (0, 40) | 0.01 | |
| Disease duration less than 6 months (%) | 2 (14) | 4 (25) | 4 (80) | 0.02 | |
| IST in past 6 months (%) | 5 (36) | 4 (25) | 1 (20) | 0.71 | |
Abbreviations: FSGS, Focal segmental glomerulosclerosis; eGFR, estimated glomerular filtration rate (mL/min/1.73m2); UPCR, Urine protein to creatinine ratio (mg/mg); IF – interstitial fibrosis; IST – immunosuppressive therapy; RAAS-renin angiotensin aldosterone system.