. Author manuscript; available in PMC: 2023 Jul 14.

Published in final edited form as: Kidney Int. 2022 Nov 25;103(3):565–579. doi: 10.1016/j.kint.2022.10.023

Table 2:

Unadjusted and adjusted Cox proportional hazards models for composite of ESKD and 40% decline in eGFR from baseline in the NEPTUNE study.

		Unadjusted Model		Adjusted for MCD/FSGS		Adjusted for MCD/FSGS, eGFR and UPCR
	Predictor	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Model 1: Cluster Membership	Cluster 1	Ref		Ref.		Ref.
	Cluster 2	1.7 (0.6, 5.1)	0.34	1.6 (0.5, 4.8)	0.40	2.3 (0.69, 7.57)	0.18
	Cluster 3	5.2 (1.9, 14.5)	0.001	4.5 (1.6, 12.9)	0.005	3.80 (1.1, 13.1)	0.035
Model 2: TNF activation score ^*	TNF Activation Score	2.6 (1.5, 4.4)	0.001	2.3 (1.3, 4.1)	0.003	1.7 (0.9, 3.5)	0.12

HR for increase in z-score by 1.

MCD, Minimal Change disease; FSGS, Focal segmental glomerulosclerosis; eGFR, estimated glomerular filtration rate (mL/min/1.73m2); UPCR, Urine protein to creatinine ratio (mg/mg)