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. 2023 Jul 11;11(7):e006788. doi: 10.1136/jitc-2023-006788

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Prediction performance of the edtCIRI27 model. Nineteen feature cytokines of edtCIRI21 model and 8 clinical and circulating factors (age, sex, stage, BMI, blood albumin of edt, NLR of edt, tumor PD-L1 expression, and treatment option) were used in edtCIRI27. (A) C-indices of edtCIRI27 model for the training and validation sets; time-dependent AUC of ROC at each time points for the (B) training and (D) validation sets; overall survival time of ‘high risk’ (high CIRI) and ‘low risk’ (low CIRI) groups predicted by preCIRI21 for the (C) training and (E) validation sets using optimized cut-off values (see online supplemental figure S7). AUC, area under the curve; BMI, body mass index; CIRI, Cytokine-based ICI Response Index; edt, early during treatment; NLR, neutrophil-to-lymphocyte ratio; ROC, receiver operating characteristic.