Table 2.
Associations with Gilbert syndrome risk alleles and demographic variables on recruitment to UK Biobank
| Characteristic | No Gilbert syndrome risk alleles (n=216 555) | Heterozygotes for Gilbert syndrome risk allele (n=200 316) | Homozygotes for Gilbert syndrome risk allele (n=46 189) |
P value* |
| Serum bilirubin (µmol/L) | 7.2 (5.9 to 8.8) | 8.5 (6.9 to 10.6) | 15.7 (12.0 to 20.4) | <0.001 |
| Sex: | 0.7 | |||
| Female | 117 140 (54) | 108 116 (54) | 24 992 (54) | |
| Male | 98 591 (46) | 91 449 (46) | 21 041 (46) | |
| Age on entry to UK Biobank (years) | 59 (51 to 64) | 59 (51 to 64) | 59 (51 to 64) | 0.8 |
| Townsend deprivation index | –2.25 (–3.70 to 0.27) | −2.26 (−3.70 to 0.28) | −2.25 (–3.68 to 0.30) | 0.4 |
| Alcohol intake frequency: | 0.004 | |||
| Daily or almost daily | 45 620 (21) | 42 024 (21) | 9375 (20) | |
| Never | 14 673 (6.8) | 13 428 (6.7) | 3261 (7.1) | |
| Once or twice a week | 56 518 (26) | 52 435 (26) | 12 110 (26) | |
| One to three times a month | 24 069 (11) | 22 124 (11) | 5278 (11) | |
| Prefer not to answer | 186 (<0.1) | 155 (<0.1) | 28 (<0.1) | |
| Special occasions only | 23 184 (11) | 21 702 (11) | 5029 (11) | |
| Three or four times a week | 51 354 (24) | 47 584 (24) | 10 930 (24) | |
| Smoking status: | 0.7 | |||
| Current | 22 526 (10) | 20 835 (10) | 4849 (11) | |
| Never | 116 001 (54) | 106 870 (54) | 24 759 (54) | |
| Prefer not to answer | 807 (0.4) | 721 (0.4) | 162 (0.4) | |
| Previous | 76 270 (35) | 71 027 (36) | 16 241 (35) | |
| Body mass index (kg/m2) | 26.7 (24.1 to 29.9) | 26.7 (24.1 to 29.9) | 26.7 (24.1 to 29.9) | 0.8 |
| Creatinine (µmol/L) | 70 (61 to 81) | 70 (61 to 81) | 70 (62 to 81) | 0.11 |
| History of liver disease | 5596 (2.6) | 5311 (2.7) | 1332 (2.9%) | 0.001 |
Data are numerator (percentage) or median (interquartile range), unless otherwise specified. *Pearson’s χ² test; Kruskal-Wallis rank sum test.