TABLE 4.
Depression-related proteins reverted by virtual lisdexamfetamine with | predicted protein activity| > 0.5 in adult, pediatric-adolescent or both virtual populations.
| Gene name | Motives in depression | ADHD effector | Population |
| BDNF | HPA axis hyperactivation/Loss of neural plasticity and Neurogenesis | Yes | Both |
| CCL2 | Neuroinflammation | No | Both |
| CREB1 | Loss of neural plasticity and neurogenesis | Yes | Both |
| CRH | HPA axis hyperactivation/Neuroinflammation | No | Both |
| CRHR1 | HPA axis hyperactivation | No | Both |
| CRP | Neuroinflammation | Yes | Both |
| CXCL8 | Neuroinflammation | No | Both |
| DRD2 | Neurotransmission alteration | Yes | Both |
| EEF2K | Loss of neural plasticity and neurogenesis | No | Both |
| FGF1 | Loss of neural plasticity and Neurogenesis/Neuroinflammation | No | Both |
| GSK3A | Loss of neural plasticity and neurogenesis | No | Both |
| GSK3B | Loss of neural plasticity and neurogenesis | No | Adult |
| HTR1A | Neurotransmission alteration | No | Both |
| IFNG | Neuroinflammation | Yes | Adult |
| IFNGR1 | Neurotransmission alteration | No | Both |
| IFNGR2 | Neurotransmission alteration | No | Both |
| IKBKB | Loss of neural plasticity and neurogenesis | No | Both |
| IL18 | Neuroinflammation | No | Both |
| IL1A | Neuroinflammation | Yes | Both |
| IL1B | Neuroinflammation | Yes | Both |
| IL2 | Neuroinflammation | Yes | Adult |
| IL6 | Neuroinflammation | Yes | Both |
| MAO | Neurotransmission alteration | Yes | Both |
| MMP2 | Neuroinflammation | No | Both |
| MTOR | Loss of neural plasticity and neurogenesis | Yes | Both |
| NFKB1 | Loss of neural plasticity and Neurogenesis/Neuroinflammation | Yes | Both |
| NLRP3 | Neuroinflammation | No | Both |
| NOS2 | Neurotransmission alteration | No | Both |
| NR3C1 | HPA axis hyperactivation | No | Both |
| NTRK2 | HPA axis hyperactivation | Yes | Both |
| POMC | HPA axis hyperactivation | No | Both |
| PPARGC1A | Glutamatergic excitotoxicity/Neuroinflammation | No | Both |
| PRKACA | Loss of neural plasticity and neurogenesis | Yes | Both |
| PRKACB | Loss of neural plasticity and neurogenesis | Yes | Both |
| RAC1 | Loss of neural plasticity and neurogenesis | No | Both |
| RPS6KB1 | Loss of neural plasticity and neurogenesis | No | Both |
| RPS6KB2 | Loss of neural plasticity and neurogenesis | No | Both |
| SERPINE1 | Loss of neural plasticity and neurogenesis | No | Both |
| SLC6A2/NET1 | Neurotransmission alteration | Yes | Both |
| SLC6A3/DAT1 | Neurotransmission alteration | Yes | Both |
| SLC6A4/SERT | Neurotransmission alteration | No | Both |
| SMAD2 | Neuroinflammation | No | Both |
| SMAD4 | Neuroinflammation | No | Adult |
| SOD1 | Oxidative stress | No | Adult |
| SOD2 | Oxidative stress | No | Both |
| STAT1 | Neuroinflammation | No | Both |
| TIMP2 | Neuroinflammation | No | Both |
| TNF | HPA axis hyperactivation/Neuroinflammation | Yes | Both |
| VAMP2 | Glutamatergic excitotoxicity | No | Both |
ADHD, attention-deficit/hyperactivity disorder; HPA, hypothalamic-pituitary-adrenal.