Table 2.
Prevalence and association of 25(OH)D deficiency (< 30 nmol/L) in T1D and NG children and adolescents (n = 444)
| Prevalence of 25(OH)D deficiency (< 30 nmol/L) | Multiple Logistic Regression | |||||
|---|---|---|---|---|---|---|
| Cases (T1D) | Controls (NG) | Age and Sex Adjusted | P-valuea | Mutually Adjusted OR [aOR] | P-value* | |
| Diabetes Status | ||||||
| Normoglycaemia | 120 (40.5%) | Ref | ||||
| Type 1 | 33 (22.3%) | 0.39 (0.24, 0.62) | 0.000 | 0.39 (0.24, 0.65) | 0.000 | |
| Vitamin D Medication | ||||||
| No | 4 (15.4%) | 17 (20.5%) | Ref | |||
| Yes | 29 (23.7%) | 103 (48.4%) | 2.08 (1.19, 3.63) | 0.009 | 2.14 (1.20, 3.81) | 0.010 |
| BMI Group | ||||||
| Normal Weight | 18 (18.7%) | 60 (38.5%) | Ref | |||
| Underweight | 2 (22.2%) | 7 (22.6%) | 0.77 (0.33, 1.79) | 0.549 | 0.73 (0.31, 1.74) | 0.482 |
| Overweight | 8 (29.6%) | 13 (37.1%) | 0.92 (0.49, 1.72) | 0.801 | 0.90 (0.47, 1.72) | 0.750 |
| Obesity | 5 (31.2%) | 40 (54.0%) | 2.69 (1.56, 4.64) | 0.000 | 2.12 (1.21, 3.71) | 0.008 |
| Age (years) | ||||||
| Children (4—< 10) | 3 (8.5%) | 10 (14.1%) | Ref | |||
| Adolescent (10–19) | 30 (26.5%) | 110 (48.9%) | - | 4.00 (2.06, 7.77) | 0.000 | |
| Sex | ||||||
| Male | 7 (10.6%) | 29 (23.6%) | Ref | |||
| Female | 26 (31.7%) | 91 (52.6%) | - | 3.19 (1.97, 5.16) | 0.000 | |
NG Normoglycaemic controls, T1D Type 1 Diabetes
aAge and sex adjusted, unconditional logistic regression
* Mutually adjusted logistic regression, model fit was assessed by a goodness of fit Hosmer–Lemeshow test (p = 0.815)