Table 1.

Development of the research question based on PICOS

PICOS Question
Population	Adult patients diagnosed as bruxers (by medical questionnaire and/or clinical examination and/or polysomnography)
Intervention	Analysis of imaging examination (2D or 3D): panoramic radiograph or cone beam computed tomography
Comparison	Density or volume of mandibular bone, without regard to the region of interest considered
Outcome	Evaluation of a difference in the volume or density of mandibular bone
Study type	Randomized or non-randomized clinical trials and observational studies (cross-sectional and longitudinal, retrospective or prospective)