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. 2023 Jul 13;23:136. doi: 10.1186/s12935-023-02978-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — SNORD15A, SNORD35B and SNORD60 as biomarkers for early diagnosis of RCC. (A): SNORD15A, SNORD35B and SNORD60 were up-regulated in US of early-stage RCC patients (n = 57) compared with healthy controls (n = 131); (B): ROC curve analysis of SNORD15A, SNORD35B and SNORD60 and their combination for early-stage RCC diagnosis; ****P < 0.0001