Table 10.
Effect of gender, smoking and EGFR mutation status on high PD-L1 expression
| Parameter | All NSCLC (N = 191) | Adenocarcinoma (n = 147) | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| Likelihood estimate (95% CI) | P | Likelihood estimate (95% CI) | P | Likelihood estimate (95% CI) | P | Likelihood estimate (95% CI) | P | |
| Male vs. female |
2.12 (0.96–4.68) |
0.087 |
1.29 (0.44–3.78) |
0.639 |
1.78 (0.76–4.14) |
0.258 |
0.63 (0.16–2.51) |
0.516 |
| Ever smoker vs. never smoker |
2.26 (1.09–4.70) |
0.042 |
.0.48 (0.13–1.84) |
0.286 |
2.66 (1.16–6.10) |
0.032 |
0.41 (0.06–2.73) |
0.354 |
| Heavy smoker vs. never/non-heavy smoker |
3.50 (1.67–7.35) |
0.001 |
3.36 (1.10–10.23) |
0.033 |
5.58 (2.32–13.44) |
< 0.0001 |
8.58 (1.69–43.61) |
0.010 |
| EGFR wild-type vs. EGFR-mutant |
5.13 (2.03–12.97) |
< 0.0001 |
4.31 (1.56–11.96) |
0.005 |
7.93 (2.60–24.22 |
< 0.0001 |
7.37 (2.22–24.48) |
0.001 |