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. 2023 Jul 13;21:224. doi: 10.1186/s12951-023-01961-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — In vivo biodistributions of FePS@PPF. a In vivo fluorescence images of mice with HOS tumors (marked by ellipses) after injection of Cy5.5-labeled FePS NSs without (FePS@PP) or with folic acid modification (FePS@PPF). b Fluorescence intensity of tumor sites obtained by Living Image software. c Ex vivo fluorescence images. d Average fluorescence intensity of main organs and tumor, **p < 0.01. e Infrared thermographic images and f Temperature changes of tumor site under laser irradiation (1064 nm, 1.0 W/cm²) at 24 h after respectively intravenous infusion of PBS, FePS@PP and FePS@PPF