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. 2023 Jul 14;12:70. doi: 10.1186/s13756-023-01272-6

Box 1.

PICOS statement

Population
Children, adults and elderly of all ages and with or without chronic conditions
Intervention
Pneumococcal, influenza and/or COVID-19 vaccination (all vaccine types)
Comparison
Vaccinated versus unvaccinated (placebo) or vaccinated with other vaccine type
Outcome
Antibiotic use (all types) or antibiotic prescriptions
Study design
Randomised controlled trials, observational studies (case-cohort, control, cross-sectional), modelling studies, cost studies