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. 2023 Jul 13;23:656. doi: 10.1186/s12885-023-11134-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — HER2 evolution from primary breast cancer to distant metastases. a The overall rate of HER2 discordance. b HER2 discordant cases in HR-positive and triple-negative breast cancers respectively. c Evolution of the HER2 status between primary tumors and metastases stratified by molecular subtypes of primary BC (Chi-square test). d Evolution of the HER2 status between primary tumors and metastases stratified by T stages of primary BC (Fisher’s exact test). BC breast cancer, N number