Table 3.

Unadjusted and Adjusted Hazard Ratios for the Association Between Ever Cigarette, E-cigarette and Cannabis Use and the Age of Onset of Mental Health Symptoms

	Cohort 1 (10th grade)		Cohort 2 (12th grade)		Cohort 3 (2 years post HS)
	Depressive symptoms
	HR [95% CI]	AHR [95% CI]	HR [95% CI]	AHR [95% CI]	HR [95% CI]	AHR [95% CI]
Cigarette (user’s vs. nonusers)	2.37 (1.77 to 3.17)	2.1 (1.49 to 2.95)	1.42 (1.13 to 1.79)	1.52 (1.51 to 2.00)	1.18 (0.94 to 1.48)	1.15 (0.90 to 1.46)
E-cigarette (user’s vs. nonusers)	1.79 (1.43 to 2.24)	1.78 (1.34 to 2.37)	1.24 (0.98 to 1.57)	1.27 (0.97 to 1.66)	1.11 (0.86 to 1.41)	1.11 (0.87 to 1.42)
Cannabis (user’s vs. nonusers)	1.78(1.42 to 2.43)	1.68 (1.27 to 2.22)	1.84 (1.35 to 2.35)	1.71(1.49 to 2.28)	1.40 (1.11 to 1.75)	1.31(1.01 to 1.70)
	Anxiety symptoms
Cigarette (user’s vs. nonusers)	1.89 (1.30 to 2.76)	1.80 (1.23 to 2.65)	1.38 (1.04 to 1.83)	1.52 (1.13 to 2.05)	1.13 (0.87 to 1.44)	1.15 (0.88 to 1.49)
E-cigarette (user’s vs. nonusers)	1.63 (1.22 to 2.18)	1.58 (1.16 to 2.17)	1.07 (0.81 to 1.42)	1.07 (0.80 to 143)	1.02 (0.79 to 1.32	1.02 (0.78 to 1.33)
Cannabis (user’s vs. nonusers)	1.54 (1.13 to 2.09)	1.47 (1.08 to 2.00)	1.60 (1.24 to 2.07)	1.46 (1.08 to 1.97)	1.22 (0.95 to 1.56)	1.11 (0.85 to 1.45)

Bold indicates statistical significance, p < .05.

AHR: adjusted for sociodemographic factors and survey.

^*Nonusers (ref).