Table 1.
Characteristics of tirofiban.
Drug name | Tirofiban |
---|---|
Chemical structure |
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Chemical name | N-(butylsulfonyl)-O-[4- (4-piperidinyl)butyl]-L-tyrosine |
Substance type | Non-peptide |
Inhibition modality | Selective competitive |
Binding modality | Reversible |
Route of administration | Intravenous |
Onset | >90% inhibition of platelet aggregation seen within 10 min |
Distribution | Vdss: 22–42 L |
Protein Binding | 65% |
Plasma Half-life | 2h |
Platelet function recovery time | 4–8 h after discontinuation |
Excretion | Urine (65%) and feces (25%) primarily as unchanged tirofiban |