Table 1.
Characteristics of tirofiban.
| Drug name | Tirofiban |
|---|---|
| Chemical structure |
|
| Chemical name | N-(butylsulfonyl)-O-[4- (4-piperidinyl)butyl]-L-tyrosine |
| Substance type | Non-peptide |
| Inhibition modality | Selective competitive |
| Binding modality | Reversible |
| Route of administration | Intravenous |
| Onset | >90% inhibition of platelet aggregation seen within 10 min |
| Distribution | Vdss: 22–42 L |
| Protein Binding | 65% |
| Plasma Half-life | 2h |
| Platelet function recovery time | 4–8 h after discontinuation |
| Excretion | Urine (65%) and feces (25%) primarily as unchanged tirofiban |