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. 2023 Jul 13;12(2):2231573. doi: 10.1080/22221751.2023.2231573

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — H1Delta protein vaccine design and structure. (A) Schematic of the H1Delta vaccine design. SP, signal peptide. (B) Representative BIAcore diagrams of H1Delta bound to the SARS-CoV-2 RBD antibody CB6 and influenza HA antibody CR9114. The K_D value was calculated using BIAevaluation Version 4.1 (GE Healthcare). (C) Cryo-EM structure of the chimeric protein in complex with the RBD-targeting CB6 antibody and the HA-stalk-targeting CR9114 antibody. (D) Overall structure of the trimeric H1Delta.