Figure 6.
Response of FLNC R9 to R15 domains to increasing time-dependent forces with loading rates of 10, 1, and 0.1 pN/s. (a) The representative curves of the height of the bead versus forces from three independent tethers at each loading rate. Each step signal represents the unfolding of one Ig-like domain. (b) The distribution of unfolding forces and the contour length released with each step signal. (c) The number of domains that unfold during each cycle.