Table 5.
MIC Distribution of Candidemia Cases Based on Candida Species and Antifungal Drug by Sensititre™ YeastOne
| Species | Total | Caspofungin | Micafungin | Anidulafungin | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S or WT | I or SDD | R or NWT | NA | MIC50 | MIC90 | S or WT | I or SDD | R or NWT | NA | MIC50 | MIC90 | S or WT | I or SDD | R or NWT | NA | MIC50 | MIC90 | ||
| C. albicans | 5 | 5 | 0 | 0 | 0 | 0.06 | 0.05 | 5 | 0 | 0 | 0 | 0.03 | 1 | 5 | 0 | 0 | 0 | 0.098 | 1 |
| C. parapsilosis | 10 | 10 | 0 | 0 | 0 | 0.12 | 0.5 | 10 | 0 | 0 | 0 | 0.12 | 1 | 10 | 0 | 0 | 0 | 0.12 | 1 |
| C. tropicalis | 3 | 3 | 0 | 0 | 0 | 0.15 | 0.5 | 3 | 0 | 0 | 0 | 0.108 | 1.15 | 3 | 0 | 0 | 0 | 0.185 | 1.15 |
| C. glabrata | 8 | 8 | 0 | 0 | 0 | 0.09 | 0.5 | 8 | 0 | 0 | 0 | 0.03 | 1 | 8 | 0 | 0 | 0 | 0.12 | 1 |
| Other Non albicans Candida* | 7 | 5 | 1 | 0 | 1 | 0.12 | 0.5 | 7 | 0 | 0 | 0 | 0.12 | 1 | 7 | 0 | 0 | 0 | 0.12 | 1 |
| Total | 33 | 31 | 1 | 0 | 1 | 0.09 | 0.5 | 33 | 0 | 0 | 0 | 0.03 | 1 | 33 | 0 | 0 | 0 | 0.12 | 1 |
| Fluconazole | Voriconazole | Itraconazole | |||||||||||||||||
| Species | Total | S or WT | I or SDD | R or NWT | NA | MIC50 | MIC90 | S or WT | I or SDD | R or NWT | NA | MIC50 | MIC90 | S or WT | I or SDD | R or NWT | NA | MIC50 | MIC90 |
| C. albicans | 5 | 5 | 0 | 0 | 0 | 1.75 | 27.2 | 5 | 0 | 0 | 0 | 0.06 | 0.5 | 3 | 0 | 2 | 0 | 0.12 | 0.443 |
| C. parapsilosis | 10 | 7 | 1 | 2 | 0 | 2 | 64 | 8 | 2 | 0 | 0 | 0.12 | 0.5 | 10 | 0 | 0 | 0 | 0.12 | 0.5 |
| C. tropicalis | 3 | 2 | 1 | 0 | 0 | 1.25 | 18 | 0 | 3 | 0 | 0 | 0.075 | 0.55 | 3 | 0 | 0 | 0 | 0.185 | 0.367 |
| C. glabrata | 8 | 0 | 8 | 0 | 0 | 2 | 64 | 6 | 0 | 2 | 0 | 0.185 | 0.5 | 8 | 0 | 0 | 0 | 0.25 | 0.5 |
| Other Non albicans Candida* | 7 | 3 | 0 | 4 | 0 | 2 | 140.8 | 4 | 0 | 0 | 3 | 0.12 | 0.7 | 7 | 0 | 0 | 3 | 0.12 | 0.5 |
| Total | 33 | 17 | 10 | 6 | 0 | 2 | 57.6 | 23 | 5 | 2 | 3 | 0.12 | 0.5 | 28 | 0 | 2 | 3 | 0.12 | 0.5 |
| Posaconazole | Flucytosine | Amphotericin B | |||||||||||||||||
| Species | Total | S or WT | I or SDD | R or NWT | NA | MIC50 | MIC90 | S or WT | R or NWT | NA | MIC50 | MIC90 | Failed | S or WT | I or SDD | R or NWT | NA | MIC50 | MIC90 |
| C. albicans | 5 | 5 | – | 0 | 0 | 0.09 | 0.68 | – | – | 1 | 4 | 5 | 0 | 0 | 0 | 0.5 | 1 | ||
| C. parapsilosis | 10 | 10 | – | 0 | 0 | 0.12 | 0.5 | – | – | 7 | 0.06 | 0.06 | 3 | 10 | 0 | 0 | 0 | 0.5 | 1 |
| C. tropicalis | 3 | 0 | – | 3 | 0 | 0.08 | 0.5 | – | – | 2 | 1 | 3 | 0 | 0 | 0 | 0.5 | 1 | ||
| C. glabrata | 8 | 8 | – | 0 | 0 | 0.12 | 0.75 | – | – | 2 | 6 | 8 | 0 | 0 | 0 | 0.5 | 1 | ||
| Other Non albicans Candida* | 7 | 4 | – | 0 | 3 | 0.12 | 0.5 | – | – | 2 | 5 | 6 | 0 | 1 | 0 | 0.5 | 1 | ||
| Total | 33 | 27 | – | 3 | 3 | 0.12 | 0.7 | – | – | 14 | 0.06 | 0.06 | 19 | 32 | 0 | 1 | 0 | 0.5 | 1 |
Notes: NA, not available breakpoints or epidemiological cut-off value, *Other Non albicans Candida includes (number): C. auris (3), C. krusei (1), C. orthopsilosis (2) and C. dublinensis (1). MIC, minimum inhibitory concentration; S, sensitive; WT, wild type; I, intermediate; SDD, susceptible dose dependent; R, resistant; NWT, non wild type.